ADAM15

Across TCGA pan-cancer cohorts, ADAM15 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ADAM15’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ADAM15 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ADAM15 is over-expressed in tumor, although a few such as HNSC and OV show the opposite, repressed pattern.

HNSC, CCRCC, and LUAD are the cancer types where ADAM15 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAM15 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−0.445	<.001	8	view →
CCRCC	Male	III,IV	+0.431	<.001	6	view →
LUAD	Female	III,IV	+0.427	.007	4	view →
OV	All	All	−0.911	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ADAM15–HNSC

Open the HNSC breakdown →