ADAM12

Across TCGA patient cohorts, ADAM12 protein abundance is significantly associated with the RNA expression of many other genes, with 5,061 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ADAM12-associated genes across cancer lineages are MXRA5, SFRP2, and LGALS1. Each is linked with ADAM12 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAM12-to-partner and partner-to-ADAM12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADAM12 versus MXRA5 in GBM, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM12→partner) and Y-score (partner→ADAM12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MXRA5 →	+2.016	+0.516	<.001	.003	3	4
HNSC	SFRP2 →	+1.857	+1.840	.001	.005	3	4
GBM	LGALS1 →	+1.402	+0.834	<.001	<.001	3	3
GBM	CCN4 →	+1.378	+0.408	<.001	.001	3	3
GBM	SERPINE1 →	+1.913	+0.695	<.001	<.001	3	3
GBM	ACTA2 →	+1.269	+0.705	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,061 associations by consensus.

ADAM12 vs MXRA5 — GBM

Explore this scatter interactively →