ADAM12

Across TCGA pan-cancer cohorts, ADAM12 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ADAM12’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ADAM12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADAM12 is over-expressed in tumor.

HNSC, BLCA, and COAD are the cancer types where ADAM12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAM12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+4.181	<.001	12	view →
BLCA	All	IV	+2.511	<.001	12	view →
COAD	Male	III,IV	+3.125	<.001	11	view →
STAD	Male	II,III,IV	+1.992	<.001	10	view →
LUAD	Male	III,IV	+3.176	<.001	9	view →
KIRC	Male	All	+1.054	<.001	9	view →
LUSC	Female	II,III,IV	+3.064	<.001	8	view →
BRCA	All	III,IV	+2.009	<.001	6	view →
KIRP	Male	All	+1.050	<.001	6	view →
READ	All	All	+2.090	.003	5	view →
THCA	All	All	+0.655	<.001	5	view →
LIHC	All	All	+0.555	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ADAM12–HNSC

Open the HNSC breakdown →