ADAM12

Across TCGA patient cohorts, ADAM12 mutation is significantly associated with the RNA expression of many other genes, with 3,863 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM12-associated genes across cancer lineages are CDT1, UQCRC1, and PKMYT1. Each is linked with ADAM12 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADAM12-to-partner and partner-to-ADAM12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDT1 grouped by ADAM12-low versus ADAM12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM12→partner) and Y-score (partner→ADAM12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDT1 →	+0.908	+2.091	<.001	<.001	3	5
SKCM	UQCRC1 →	+0.355	+3.182	.006	.009	3	4
LUAD	PKMYT1 →	+0.678	+2.709	.008	.003	3	4
UCEC	KIF22 →	+0.399	+2.069	.004	<.001	3	4
UCEC	ZMYND19 →	+0.540	+2.410	<.001	<.001	3	4
SKCM	AURKB →	+0.564	+2.106	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,863 associations by consensus.

CDT1 by ADAM12 expression — UCEC

Explore this box plot interactively →