ADAM12

Across TCGA cell cohorts, ADAM12 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,047 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ADAM12-associated GO terms across cancer lineages are Positive regulation of supramolecular fiber organization, Viral process, and Positive regulation of stress fiber assembly. Each is linked with ADAM12 in more than 12 cancer types. Because this analysis shows association rather than direction, both ADAM12-to-partner and partner-to-ADAM12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of supramolecular fiber organization grouped by ADAM12-low versus ADAM12-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM12→partner) and Y-score (partner→ADAM12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of supramolecular fiber organization →	+0.087	+2.375	<.001	.001	3	13
BONE	Viral process →	+0.081	+3.320	<.001	<.001	3	12
BONE	Positive regulation of stress fiber assembly →	+0.158	+3.138	<.001	<.001	3	12
BONE	Positive regulation of cell-substrate junction organization →	+0.155	+3.119	<.001	<.001	3	11
BONE	Regulation of cell-matrix adhesion →	+0.156	+3.435	<.001	<.001	3	11
BONE	Positive regulation of actin filament bundle assembly →	+0.164	+3.075	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,047 associations by consensus.

Positive regulation of supramolecular fiber organization by ADAM12 expression — LIVER

Explore this box plot interactively →