ADAM12

Across TCGA cell cohorts, ADAM12 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM12-associated genes across cancer lineages are OR6B3, HHLA1, and NOBOX. Each is linked with ADAM12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM12-to-partner and partner-to-ADAM12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6B3 grouped by ADAM12-low versus ADAM12-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM12→partner) and Y-score (partner→ADAM12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR6B3 →	+0.037	+3.353	<.001	.002	3	2
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	2
BLOOD_Lymphoma	NOBOX →	+0.002	+3.925	<.001	.006	3	1
BLOOD_Lymphoma	MAGEB4 →	+0.607	+2.874	<.001	.009	3	1
BLOOD_Lymphoma	PLA2G7 →	+0.028	+2.956	.002	.008	3	1
BLOOD_Lymphoma	IHH →	+0.043	+3.421	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

OR6B3 by ADAM12 expression — BLOOD_Lymphoma

Explore this box plot interactively →