ADAM11

Across TCGA cell cohorts, ADAM11 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ADAM11-associated genes across cancer lineages are OR52E8, OOSP4B, and VN1R2. Each is linked with ADAM11 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM11-to-partner and partner-to-ADAM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E8 grouped by ADAM11-low versus ADAM11-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM11→partner) and Y-score (partner→ADAM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR52E8 →	+0.053	+5.643	<.001	.002	3	1
LUNG_SCLC	OOSP4B →	+0.233	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	VN1R2 →	+0.009	+4.643	<.001	.005	3	1
LUNG_NSCLC_LUAD	DEFB124 →	+0.120	+3.980	<.001	.002	3	1
LUNG_NSCLC_LUAD	APOC4 →	+0.033	+4.266	<.001	.004	3	1
CNS	IL21 →	+0.028	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR52E8 by ADAM11 expression — LUNG_SCLC

Explore this box plot interactively →