ADAM10

Across TCGA cell cohorts, ADAM10 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAM10-associated genes across cancer lineages are OR14K1, GLIS1, and TAFA1. Each is linked with ADAM10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM10-to-partner and partner-to-ADAM10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14K1 grouped by ADAM10-low versus ADAM10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM10→partner) and Y-score (partner→ADAM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR14K1 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GLIS1 →	+0.268	+3.669	<.001	.008	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
BLOOD_Leukemia	IL4 →	+1.320	+4.007	.005	.002	3	1
BLOOD_Leukemia	KAAG1 →	+0.081	+4.177	<.001	.001	3	1
BLOOD_Leukemia	ASZ1 →	+0.098	+3.567	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR14K1 by ADAM10 expression — LARGE_INTESTINE

Explore this box plot interactively →