ADAL

Across TCGA patient cohorts, ADAL protein abundance is significantly associated with the RNA expression of many other genes, with 9,876 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ADAL-associated genes across cancer lineages are EMC4, CHST14, and TP53BP1. Each is linked with ADAL in more than 4 cancer types. Because this analysis shows association rather than direction, both ADAL-to-partner and partner-to-ADAL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADAL versus EMC4 in LSCC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAL→partner) and Y-score (partner→ADAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EMC4 →	+0.420	+0.243	<.001	<.001	3	4
LSCC	CHST14 →	+0.571	+0.212	<.001	.004	2	5
BRCA	TP53BP1 →	+0.616	+0.357	.001	<.001	3	4
BRCA	GNB5 →	+0.505	+0.319	<.001	<.001	3	4
BRCA	SNTA1 →	+0.963	+0.383	<.001	<.001	3	4
LUAD	CIB2 →	+0.690	+0.311	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,876 associations by consensus.

ADAL vs EMC4 — LSCC

Explore this scatter interactively →