ADAL

Across TCGA patient cohorts, ADAL mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAL-associated genes across cancer lineages are 4E-BP1, ERK2, and NDRG1_pT346. Each is linked with ADAL in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAL-to-partner and partner-to-ADAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ADAL-low versus ADAL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAL→partner) and Y-score (partner→ADAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.323	+3.584	.013	.002	3	2
UCEC	ERK2 →	+0.206	+3.169	.027	.019	3	1
UCEC	NDRG1_pT346 →	-0.547	-2.459	.021	.020	3	1
UCEC	PDCD4 →	-0.500	-2.999	.027	.035	3	1
UCEC	Rab25 →	-0.499	-2.459	.001	.020	3	1
UCEC	Shc_pY317 →	-0.153	-2.459	.037	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

4E-BP1 by ADAL expression — UCEC

Explore this box plot interactively →