ADAL

Across TCGA cell cohorts, ADAL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,043 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAL-associated GO terms across cancer lineages are Double-strand break repair via nonhomologous end joining, Microtubule polymerization, and Microtubule nucleation. Each is linked with ADAL in more than 15 cancer types. Because this analysis shows association rather than direction, both ADAL-to-partner and partner-to-ADAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via nonhomologous end joining grouped by ADAL-low versus ADAL-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAL→partner) and Y-score (partner→ADAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.059	+0.830	.007	.004	2	16
LIVER	Microtubule polymerization →	+0.127	+0.754	.002	.002	2	16
BLOOD_Leukemia	Microtubule nucleation →	+0.104	+0.859	<.001	<.001	3	14
SOFT_TISSUE	Regulation of DNA damage checkpoint →	+0.093	+0.954	<.001	.003	2	14
SOFT_TISSUE	Negative regulation of cell cycle G2/M phase transition →	+0.106	+1.227	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Protein polymerization →	+0.076	+1.214	.006	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,043 associations by consensus.

Double-strand break repair via nonhomologous end joining by ADAL expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →