ADAD2

Across TCGA cell cohorts, ADAD2 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAD2-associated genes across cancer lineages are AVPR1B, KRTAP2-1, and MS4A6E. Each is linked with ADAD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAD2-to-partner and partner-to-ADAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVPR1B grouped by ADAD2-low versus ADAD2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAD2→partner) and Y-score (partner→ADAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AVPR1B →	+0.009	+4.415	<.001	.007	3	1
SKIN	KRTAP2-1 →	+0.193	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	MS4A6E →	+0.044	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	C16orf82 →	+0.013	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	KRTAP10-11 →	+0.018	+4.887	<.001	.009	3	1
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

AVPR1B by ADAD2 expression — SKIN

Explore this box plot interactively →