ACY3

Across TCGA pan-cancer cohorts, ACY3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ACY3 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ACY3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ACY3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where ACY3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.849	0.215	.010	24	view →
UCEC	DFS	Median	All	0.981	0.855	.008	12	view →
CCRCC	OS	Tertile	All	1.000	0.892	.023	11	view →
PDAC	OS	Quartile	II,III,IV	0.994	0.673	.003	11	view →
LSCC	OS	Tertile	II,III,IV	0.341	0.989	.038	6	view →
LUAD	DFS	Tertile	II,III,IV	0.439	0.888	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ACY3–HNSC (DFS)

Open the HNSC breakdown →