ACY1

Across TCGA pan-cancer cohorts, ACY1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ACY1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ACY1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ACY1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where ACY1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.897	0.718	.004	30	view →
PDAC	DFS	Quartile	All	0.430	0.181	.005	17	view →
LUAD	OS	Median	II,III,IV	0.439	0.839	.001	17	view →
LSCC	OS	Quartile	All	0.770	0.966	.022	5	view →
GBM	DFS	Tertile	All	0.629	0.830	.012	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ACY1–CCRCC (DFS)

Open the CCRCC breakdown →