ACY1

Across TCGA pan-cancer cohorts, ACY1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ACY1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ACY1 RNA is repressed in tumor relative to normal tissue. In most cancer types ACY1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and LUAD are the cancer types where ACY1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACY1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−1.492	<.001	12	view →
KIRP	Male	III,IV	−2.079	<.001	10	view →
LUAD	Female	II,III,IV	+0.567	<.001	8	view →
KICH	All	II,III,IV	−2.043	<.001	7	view →
BLCA	All	III,IV	+1.022	<.001	7	view →
UCEC	All	All	+0.546	.008	6	view →
THCA	Female	All	+0.366	<.001	5	view →
COAD	All	All	+0.359	.007	5	view →
LUSC	Male	All	+0.373	<.001	4	view →
CHOL	All	All	−1.054	<.001	3	view →
PAAD	All	All	+0.872	.013	2	view →
PRAD	All	All	+0.612	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ACY1–KIRC

Open the KIRC breakdown →