ACVR2A

Across TCGA pan-cancer cohorts, ACVR2A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ACVR2A data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ACVR2A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACVR2A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, UCEC, and CHOL are the cancer types where ACVR2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	0.087	0.708	<.001	23	view →
UCEC	DFS	Median	All	0.951	0.612	.004	16	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ACVR2A–SKCM (DFS)

Open the SKCM breakdown →