ACVR2A

Across TCGA pan-cancer cohorts, ACVR2A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ACVR2A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ACVR2A RNA is repressed in tumor relative to normal tissue. In most cancer types ACVR2A is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and BRCA are the cancer types where ACVR2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACVR2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.249	<.001	10	view →
KIRC	Male	III,IV	−0.646	<.001	8	view →
BRCA	Female	All	−0.684	<.001	6	view →
COAD	Female	All	−0.601	.001	4	view →
CHOL	All	All	+1.225	<.001	3	view →
READ	All	II,III,IV	−0.660	.034	3	view →
HNSC	All	All	−0.299	.031	3	view →
THCA	All	All	−0.242	.013	3	view →
PAAD	Male	All	+0.835	.002	2	view →
UCEC	All	All	−0.517	.005	2	view →
LUAD	All	III,IV	−0.338	.013	2	view →
LUSC	Female	All	+0.552	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ACVR2A–KICH

Open the KICH breakdown →