ACVR2A

Across TCGA patient cohorts, ACVR2A mutation is significantly associated with the RNA expression of many other genes, with 3,964 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACVR2A-associated genes across cancer lineages are RN7SL134P, RPL35AP3, and MFFP3. Each is linked with ACVR2A in more than 3 cancer types. Because this analysis shows association rather than direction, both ACVR2A-to-partner and partner-to-ACVR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by ACVR2A-low versus ACVR2A-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVR2A→partner) and Y-score (partner→ACVR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL134P →	+0.136	+3.874	<.001	.006	3	4
UCEC	RPL35AP3 →	+0.149	+1.916	.001	<.001	3	3
SKCM	MFFP3 →	+0.252	+3.906	<.001	.001	3	2
SKCM	HDAC9-AS1 →	+0.155	+3.744	<.001	.003	3	2
SKCM	SAR1AP1 →	+0.120	+3.587	<.001	.002	3	2
UCEC	DPY19L4P2 →	+0.053	+1.339	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,964 associations by consensus.

RN7SL134P by ACVR2A expression — CESC

Explore this box plot interactively →