ACVR2A

Across TCGA patient cohorts, ACVR2A mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACVR2A-associated genes across cancer lineages are ASNS, ATM, and eIF4G. Each is linked with ACVR2A in more than 2 cancer types. Because this analysis shows association rather than direction, both ACVR2A-to-partner and partner-to-ACVR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ACVR2A-low versus ACVR2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVR2A→partner) and Y-score (partner→ACVR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.757	+2.593	<.001	.006	3	3
UCEC	ATM →	-0.724	-2.321	<.001	<.001	3	3
UCEC	eIF4G →	+0.262	+1.184	.004	.022	3	2
COAD	FASN →	+0.418	+1.882	.010	.031	3	2
UCEC	FoxM1 →	+0.201	+1.584	.009	.002	3	2
UCEC	FOXO3a_pS318_S321 →	-0.097	-1.642	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

ASNS by ACVR2A expression — COAD

Explore this box plot interactively →