ACVR2A

Across TCGA cell cohorts, ACVR2A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,860 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ACVR2A-associated GO terms across cancer lineages are Late viral transcription, Positive regulation of cytoplasmic translation, and Regulation of alternative mRNA splicing, via spliceosome. Each is linked with ACVR2A in more than 12 cancer types. Because this analysis shows association rather than direction, both ACVR2A-to-partner and partner-to-ACVR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Late viral transcription grouped by ACVR2A-low versus ACVR2A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVR2A→partner) and Y-score (partner→ACVR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Late viral transcription →	+0.152	+0.927	<.001	<.001	3	13
STOMACH	Positive regulation of cytoplasmic translation →	+0.114	+0.875	.003	.005	2	13
SOFT_TISSUE	Regulation of alternative mRNA splicing, via spliceosome →	+0.100	+1.631	<.001	<.001	3	11
BREAST	Protein sumoylation →	+0.057	+0.567	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Protein localization to vacuole →	+0.090	+0.638	<.001	.002	3	10
LUNG_SCLC	Post-transcriptional gene silencing →	+0.080	+1.147	<.001	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,860 associations by consensus.

Late viral transcription by ACVR2A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →