ACVR2A

Across TCGA cell cohorts, ACVR2A mutation is significantly associated with the RNA expression of many other genes, with 1,995 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACVR2A-associated genes across cancer lineages are MSH4, C1QB, and DAO. Each is linked with ACVR2A in more than 1 cancer types. Because this analysis shows association rather than direction, both ACVR2A-to-partner and partner-to-ACVR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH4 grouped by ACVR2A-low versus ACVR2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVR2A→partner) and Y-score (partner→ACVR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSH4 →	+0.297	+2.320	<.001	<.001	3	2
STOMACH	C1QB →	+0.029	+3.209	<.001	.007	3	1
OVARY	DAO →	+0.056	+3.263	<.001	.006	3	1
OVARY	ASB17 →	+0.011	+3.807	<.001	.009	3	1
OVARY	OR1L3 →	+0.027	+3.444	.002	.003	3	1
OVARY	ASCL3 →	+0.145	+3.459	.003	.008	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,995 associations by consensus.

MSH4 by ACVR2A expression — LARGE_INTESTINE

Explore this box plot interactively →