ACVR1B

Across TCGA patient cohorts, ACVR1B mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACVR1B-associated genes across cancer lineages are C-Raf, Cyclin-B1, and c-Myc. Each is linked with ACVR1B in more than 2 cancer types. Because this analysis shows association rather than direction, both ACVR1B-to-partner and partner-to-ACVR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ACVR1B-low versus ACVR1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVR1B→partner) and Y-score (partner→ACVR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.138	+1.584	.001	.017	3	3
UCEC	Cyclin-B1 →	+0.429	+1.765	.012	.013	3	3
COAD	c-Myc →	-0.251	-3.157	.018	.018	3	2
COAD	Cyclin-E1 →	+0.330	+2.330	.003	.020	3	2
UCEC	EGFR →	-0.129	-1.906	.008	.015	3	1
UCEC	eIF4E →	+0.140	+3.713	.030	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

C-Raf by ACVR1B expression — UCEC

Explore this box plot interactively →