ACVR1B

Across TCGA pan-cancer cohorts, ACVR1B RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated ACVR1B data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher ACVR1B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACVR1B expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

LIHC, UCS, and UCEC are the cancer types where ACVR1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	All	0.451	0.628	<.001	57	view →
UCS	OS	Quartile	II,III,IV	0.687	0.226	.014	40	view →
UCEC	DFS	Tertile	All	0.787	0.869	.016	34	view →
MESO	OS	Median	All	0.463	0.635	.004	15	view →
HNSC	OS	Quartile	All	0.305	0.634	.005	14	view →
SKCM	DFS	Median	III,IV	0.194	0.345	.026	9	view →
READ	DFS	Median	III,IV	0.614	0.361	.019	6	view →
OV	DFS	Quartile	All	0.574	0.478	.027	6	view →
LGG	OS	Tertile	All	0.802	0.968	.003	6	view →
KIRC	OS	Median	All	0.688	0.574	.033	4	view →
LAML	DFS	Median	All	0.686	0.465	.038	4	view →
ACC	OS	Median	III,IV	0.793	0.432	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

ACVR1B–LIHC (DFS)

Open the LIHC breakdown →