ACVR1B

Across TCGA cell cohorts, ACVR1B mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ACVR1B-associated genes across cancer lineages are TBC1D21, LILRA1, and KRT71. Each is linked with ACVR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both ACVR1B-to-partner and partner-to-ACVR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by ACVR1B-low versus ACVR1B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVR1B→partner) and Y-score (partner→ACVR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TBC1D21 →	+0.023	+5.977	<.001	.001	3	2
SOFT_TISSUE	LILRA1 →	+0.113	+4.930	<.001	.008	3	1
SOFT_TISSUE	KRT71 →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	ZAN →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	LILRA5 →	+0.345	+4.930	<.001	.008	3	1
SOFT_TISSUE	DTHD1 →	+0.006	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

TBC1D21 by ACVR1B expression — SOFT_TISSUE

Explore this box plot interactively →