ACTR5

Across TCGA cell cohorts, ACTR5 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACTR5-associated genes across cancer lineages are TLX3, SMIM36, and APOA4. Each is linked with ACTR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR5-to-partner and partner-to-ACTR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLX3 grouped by ACTR5-low versus ACTR5-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR5→partner) and Y-score (partner→ACTR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TLX3 →	+0.717	+3.523	<.001	.009	3	1
URINARY_TRACT	SMIM36 →	+0.023	+3.584	<.001	.005	3	1
LUNG_NSCLC_LUAD	APOA4 →	+0.027	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.003	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP9-9 →	+0.012	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	CD300LD →	+0.115	+3.947	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

TLX3 by ACTR5 expression — URINARY_TRACT

Explore this box plot interactively →