ACTR3C

Across TCGA cell cohorts, ACTR3C RNA expression is significantly associated with the go_rna of many other GO terms, with 3,712 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ACTR3C-associated GO terms across cancer lineages are Response to unfolded protein, Regulation of amyloid fibril formation, and Negative regulation of Arp2/3 complex-mediated actin nucleation. Each is linked with ACTR3C in more than 8 cancer types. Because this analysis shows association rather than direction, both ACTR3C-to-partner and partner-to-ACTR3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to unfolded protein grouped by ACTR3C-low versus ACTR3C-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR3C→partner) and Y-score (partner→ACTR3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Response to unfolded protein →	+0.085	+0.956	.001	.003	3	8
URINARY_TRACT	Regulation of amyloid fibril formation →	+0.111	+1.622	.009	.002	2	9
BREAST	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.110	+0.926	.001	.001	3	8
LIVER	Endosome organization →	+0.084	+1.800	.005	.006	3	8
LUNG_SCLC	Paracellular transport →	+0.941	+1.176	<.001	<.001	3	7
STOMACH	Intestinal absorption →	+0.169	+0.887	.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,712 associations by consensus.

Response to unfolded protein by ACTR3C expression — PANCREAS

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