ACTR3C

Across TCGA pan-cancer cohorts, ACTR3C RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ACTR3C data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ACTR3C RNA is associated with better overall survival. In most high-consensus cancer types, elevated ACTR3C expression acts as an unfavorable survival marker, although some lineages such as ACC and MESO show a favorable association.

ACC, CESC, and GBM are the cancer types where ACTR3C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.828	0.426	<.001	85	view →
CESC	DFS	Quartile	II,III,IV	0.238	0.733	.001	58	view →
GBM	OS	Median	All	0.318	0.510	<.001	42	view →
PAAD	OS	Median	II,III,IV	0.345	0.539	.004	42	view →
MESO	DFS	Median	IV	0.491	0.156	.002	41	view →
STAD	OS	Tertile	III,IV	0.690	0.480	.017	40	view →
BLCA	OS	Median	All	0.775	0.658	.007	29	view →
PRAD	DFS	Tertile	All	0.914	0.713	.004	24	view →
LGG	OS	Tertile	All	0.811	0.911	.007	18	view →
UCS	DFS	Tertile	IV	0.975	0.361	.024	18	view →
LUSC	OS	Tertile	III,IV	0.810	0.490	.010	17	view →
UVM	DFS	Quartile	II,III,IV	0.308	0.653	.028	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ACTR3C–ACC (OS)

Open the ACC breakdown →