ACTR3

Across TCGA patient cohorts, ACTR3 protein abundance is significantly associated with the RNA expression of many other genes, with 21,134 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ACTR3-associated genes across cancer lineages are SPN, IFFO1, and ITK. Each is linked with ACTR3 in more than 8 cancer types. Because this analysis shows association rather than direction, both ACTR3-to-partner and partner-to-ACTR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACTR3 versus SPN in BRCA, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR3→partner) and Y-score (partner→ACTR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPN →	+0.825	+0.243	<.001	<.001	3	9
OV	IFFO1 →	+0.690	+0.178	<.001	<.001	3	8
BRCA	ITK →	+0.882	+0.268	<.001	<.001	3	8
BRCA	WIPF1 →	+0.811	+0.282	<.001	<.001	3	8
OV	TRAT1 →	+0.941	+0.319	<.001	<.001	3	8
CCRCC	SAMD3 →	+0.535	+0.218	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,134 associations by consensus.

ACTR3 vs SPN — BRCA

Explore this scatter interactively →