ACTR3

Across TCGA pan-cancer cohorts, ACTR3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ACTR3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ACTR3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ACTR3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where ACTR3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACTR3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.838	<.001	12	view →
KIRC	Female	All	+0.624	<.001	11	view →
LIHC	All	II,III,IV	+0.897	<.001	9	view →
KIRP	All	II,III,IV	+0.785	<.001	9	view →
STAD	All	II,III,IV	+0.676	<.001	8	view →
LUSC	Male	All	+0.661	<.001	6	view →
BRCA	All	III,IV	+0.646	<.001	6	view →
CHOL	Male	All	+2.216	<.001	5	view →
KICH	Female	II,III,IV	−1.497	<.001	5	view →
LUAD	Male	All	+0.542	<.001	5	view →
THCA	Female	All	−0.300	.015	2	view →
COAD	All	II,III,IV	+0.203	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ACTR3–HNSC

Open the HNSC breakdown →