ACTR3

Across TCGA patient cohorts, ACTR3 mutation is significantly associated with the RNA expression of many other genes, with 1,451 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTR3-associated genes across cancer lineages are NPLP1, RNU6-618P, and BPY2DP. Each is linked with ACTR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR3-to-partner and partner-to-ACTR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPLP1 grouped by ACTR3-low versus ACTR3-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR3→partner) and Y-score (partner→ACTR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	NPLP1 →	+0.291	+5.421	<.001	.005	3	2
UCEC	RNU6-618P →	+0.285	+2.854	<.001	<.001	3	2
COAD	BPY2DP →	+0.230	+6.409	<.001	<.001	3	2
LUSC	PPBPP1 →	+0.108	+4.853	.002	.004	3	2
READ	CGB2 →	+1.019	+5.219	<.001	.006	3	1
READ	RNU6-940P →	+0.472	+6.681	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,451 associations by consensus.

NPLP1 by ACTR3 expression — READ

Explore this box plot interactively →