ACTR3

Across TCGA patient cohorts, ACTR3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTR3-associated genes across cancer lineages are MAPK_pT202_Y204, mTOR_pS2448, and NF-kB-p65_pS536. Each is linked with ACTR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR3-to-partner and partner-to-ACTR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by ACTR3-low versus ACTR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR3→partner) and Y-score (partner→ACTR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.471	-3.169	.021	.019	3	1
UCEC	mTOR_pS2448 →	-0.141	-3.439	.030	.005	3	1
UCEC	NF-kB-p65_pS536 →	-0.435	-2.115	.028	.019	3	1
UCEC	PCNA →	+0.314	+3.321	<.001	.009	3	1
UCEC	Rictor_pT1135 →	-0.106	-3.169	.018	.019	3	1
UCEC	VHL →	-0.803	-2.321	.006	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MAPK_pT202_Y204 by ACTR3 expression — UCEC

Explore this box plot interactively →