ACTN1

Across TCGA cell cohorts, ACTN1 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACTN1-associated genes across cancer lineages are OXT, TAS2R60, and TEX51. Each is linked with ACTN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTN1-to-partner and partner-to-ACTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by ACTN1-low versus ACTN1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN1→partner) and Y-score (partner→ACTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OXT →	+0.033	+3.523	.002	.009	3	1
BLOOD_Lymphoma	TAS2R60 →	+0.042	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	TEX51 →	+0.015	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.026	+4.662	<.001	.003	3	1
URINARY_TRACT	CSN1S1 →	+0.251	+3.584	.007	.005	3	1
URINARY_TRACT	HTN1 →	+0.157	+4.044	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

OXT by ACTN1 expression — BLOOD_Lymphoma

Explore this box plot interactively →