ACTN1-AS1

Across TCGA pan-cancer cohorts, ACTN1-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ACTN1-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ACTN1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACTN1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

KIRC, ACC, and COAD are the cancer types where ACTN1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.466	0.692	<.001	105	view →
ACC	OS	Tertile	All	0.422	0.871	<.001	85	view →
COAD	OS	Tertile	All	0.503	0.708	.004	64	view →
LGG	DFS	Median	All	0.666	0.799	<.001	50	view →
KICH	OS	Median	III,IV	0.559	0.928	.007	29	view →
STAD	OS	Quartile	All	0.414	0.616	.010	26	view →
LIHC	DFS	Median	All	0.481	0.594	.006	23	view →
UCS	OS	Quartile	All	0.675	0.303	.012	18	view →
SKCM	DFS	Tertile	II,III,IV	0.352	0.190	.011	17	view →
ESCA	DFS	Tertile	III,IV	0.589	0.273	.033	11	view →
KIRP	DFS	Median	All	0.486	0.745	.016	9	view →
MESO	DFS	Quartile	All	0.206	0.422	.028	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ACTN1-AS1–KIRC (DFS)

Open the KIRC breakdown →