ACTN1-AS1

Across TCGA pan-cancer cohorts, ACTN1-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ACTN1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ACTN1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ACTN1-AS1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, BRCA, and LIHC are the cancer types where ACTN1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACTN1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.283	<.001	8	view →
BRCA	All	All	−0.253	<.001	6	view →
LIHC	Male	All	+0.113	<.001	6	view →
BLCA	All	All	−0.327	.004	5	view →
THCA	All	II,III,IV	+0.192	.004	5	view →
COAD	All	All	+0.139	.004	5	view →
LUAD	All	All	+0.130	.001	5	view →
LUSC	Male	II,III,IV	+0.250	<.001	4	view →
HNSC	All	III,IV	+0.188	.008	4	view →
UCEC	All	All	−0.354	.007	2	view →
STAD	Male	II,III,IV	+0.237	.015	2	view →
CHOL	Male	All	+0.126	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ACTN1-AS1–KICH

Open the KICH breakdown →