ACTL8

Across TCGA cell cohorts, ACTL8 mutation is significantly associated with the mutation status of many other genes, with 3,289 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACTL8-associated genes across cancer lineages are MYH9, EIF4G3, and MYH14. Each is linked with ACTL8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTL8-to-partner and partner-to-ACTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH9 grouped by ACTL8-low versus ACTL8-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL8→partner) and Y-score (partner→ACTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MYH9 →	+4.044	+5.000	.008	.008	1	3
CNS	EIF4G3 →	+6.044	+6.044	.001	.001	1	3
BLOOD_Leukemia	MYH14 →	+2.378	+3.452	.005	.005	1	3
LUNG_SCLC	GIMAP2 →	+4.502	+5.066	.007	.007	1	3
SKIN	SPNS3 →	+4.824	+5.392	.004	.004	1	3
CNS	NLRP3 →	+4.459	+5.277	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,289 associations by consensus.

MYH9 by ACTL8 expression — CNS

Explore this box plot interactively →