ACTL7B

Across TCGA patient cohorts, ACTL7B mutation is significantly associated with the RNA expression of many other genes, with 1,806 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTL7B-associated genes across cancer lineages are PRXL2C, WASF2, and PBX3. Each is linked with ACTL7B in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTL7B-to-partner and partner-to-ACTL7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRXL2C grouped by ACTL7B-low versus ACTL7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL7B→partner) and Y-score (partner→ACTL7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRXL2C →	+0.501	+3.332	.002	.005	3	2
UCEC	WASF2 →	+0.537	+2.230	.001	.006	3	2
UCEC	PBX3 →	+0.802	+3.700	<.001	.001	3	2
UCEC	TRUB2 →	+0.395	+2.637	.001	.005	3	2
UCEC	DOLPP1 →	+0.645	+3.742	<.001	<.001	3	2
UCEC	MUS81 →	+0.355	+3.332	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,806 associations by consensus.

PRXL2C by ACTL7B expression — UCEC

Explore this box plot interactively →