ACTL7B

Across TCGA patient cohorts, ACTL7B mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ACTL7B-associated genes across cancer lineages are 4E-BP1_pT37_T46, STAT3_pY705, and Caspase-7-cleavedD198. Each is linked with ACTL7B in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTL7B-to-partner and partner-to-ACTL7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by ACTL7B-low versus ACTL7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL7B→partner) and Y-score (partner→ACTL7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT37_T46 →	-0.362	-2.000	.032	.032	3	3
UCEC	STAT3_pY705 →	-0.307	-2.311	.009	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.671	+3.341	.012	.005	3	2
SKCM	FOXO3a_pS318_S321 →	-0.144	-3.442	.033	.005	3	2
SKCM	PDCD4 →	-0.471	-3.459	.018	.005	3	2
UCEC	MSH2 →	-0.287	-2.973	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

4E-BP1_pT37_T46 by ACTL7B expression — UCEC

Explore this box plot interactively →