Across TCGA patient cohorts, ACTL7A mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTL7A-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and p62 Lck ligand. Each is linked with ACTL7A in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTL7A-to-partner and partner-to-ACTL7A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL7A→partner) and Y-score (partner→ACTL7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.316	+1.906	.003	.016	3	3
UCEC	14-3-3_beta →	-0.082	-2.295	.042	.033	3	2
UCEC	p62 Lck ligand →	+0.316	+2.415	.016	.003	3	2
UCEC	TIGAR →	+0.124	+1.512	.043	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.806	+2.604	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.266	-2.115	.008	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

ACTL7A survival (RNA) · tumor vs normal (RNA) · all ACTL7A data types