Across TCGA pan-cancer cohorts, ACTL7A RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ACTL7A’s most consistent transcriptional readouts.

The strongest signal is observed in esophageal carcinoma (ESCA), where ACTL7A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ACTL7A is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

ESCA and KICH are the cancer types where ACTL7A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACTL7A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
ESCA	Female	All	+0.036	.037	1	view →
KICH	All	All	−0.014	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: ACTL7A RNA expression & survival · all ACTL7A data types