Across TCGA cell cohorts, ACTL7A mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible ACTL7A-associated genes across cancer lineages are RTP1, CCR8, and GPX6. Each is linked with ACTL7A in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTL7A-to-partner and partner-to-ACTL7A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL7A→partner) and Y-score (partner→ACTL7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RTP1 →	+0.978	+4.222	<.001	.007	3	1
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1
SOFT_TISSUE	GPX6 →	+0.017	+4.369	<.001	.008	3	1
SOFT_TISSUE	DPRX →	+0.028	+4.369	.002	.008	3	1
URINARY_TRACT	XAGE5 →	+0.353	+5.087	<.001	.004	3	1
URINARY_TRACT	MPC1L →	+0.083	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

ACTL7A survival (RNA) · tumor vs normal (RNA) · all ACTL7A data types