ACTL6A

Across TCGA patient cohorts, ACTL6A protein abundance is significantly associated with the RNA expression of many other genes, with 18,358 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ACTL6A-associated genes across cancer lineages are HAUS8, CENPJ, and GMPS. Each is linked with ACTL6A in more than 6 cancer types. Because this analysis shows association rather than direction, both ACTL6A-to-partner and partner-to-ACTL6A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACTL6A versus HAUS8 in BRCA, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL6A→partner) and Y-score (partner→ACTL6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HAUS8 →	+0.674	+0.254	<.001	<.001	3	7
GBM	CENPJ →	+0.761	+0.274	<.001	<.001	3	7
LSCC	GMPS →	+1.013	+0.425	<.001	<.001	3	7
HNSC	CDCA7L →	+0.914	+0.252	<.001	<.001	3	7
BRCA	MEX3A →	+1.476	+0.257	<.001	<.001	3	7
UCEC	CAD →	+0.771	+0.255	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,358 associations by consensus.

ACTL6A vs HAUS8 — BRCA

Explore this scatter interactively →