ACTL6A

Across TCGA patient cohorts, ACTL6A mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTL6A-associated genes across cancer lineages are Rab25, ATM, and EGFR_pY1068. Each is linked with ACTL6A in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTL6A-to-partner and partner-to-ACTL6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by ACTL6A-low versus ACTL6A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL6A→partner) and Y-score (partner→ACTL6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.360	-3.584	.024	.002	3	2
UCEC	ATM →	-0.750	-3.000	<.001	.036	3	2
UCEC	EGFR_pY1068 →	-0.285	-2.459	.018	.020	2	2
UCEC	eIF4E →	+0.220	+3.584	.031	.002	3	1
UCEC	FoxM1 →	+0.326	+2.999	.009	.035	3	1
UCEC	INPP4B →	-0.394	-3.169	.011	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Rab25 by ACTL6A expression — UCEC

Explore this box plot interactively →