ACTL6A

Across TCGA cell cohorts, ACTL6A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,220 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ACTL6A-associated GO terms across cancer lineages are DNA-templated DNA replication, Negative regulation of cell cycle process, and Mitotic chromosome condensation. Each is linked with ACTL6A in more than 16 cancer types. Because this analysis shows association rather than direction, both ACTL6A-to-partner and partner-to-ACTL6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by ACTL6A-low versus ACTL6A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL6A→partner) and Y-score (partner→ACTL6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA-templated DNA replication →	+0.144	+0.836	.007	.009	3	17
BLOOD_Myeloma	Negative regulation of cell cycle process →	+0.069	+0.955	<.001	<.001	3	16
PANCREAS	Mitotic chromosome condensation →	+0.171	+0.804	<.001	<.001	3	16
PANCREAS	Regulation of chromosome separation →	+0.168	+1.000	<.001	<.001	3	15
BONE	Positive regulation of chromosome condensation →	+0.271	+0.979	.005	.001	3	15
LUNG_NSCLC_LUSC	Maintenance of centrosome location →	+0.179	+1.401	.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,220 associations by consensus.

DNA-templated DNA replication by ACTL6A expression — BONE

Explore this box plot interactively →