ACTL10

Across TCGA cell cohorts, ACTL10 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,764 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACTL10-associated GO terms across cancer lineages are Cellular response to phorbol 13-acetate 12-myristate, Regulation of cytokine-mediated signaling pathway, and Regulation of protein export from nucleus. Each is linked with ACTL10 in more than 10 cancer types. Because this analysis shows association rather than direction, both ACTL10-to-partner and partner-to-ACTL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to phorbol 13-acetate 12-myristate grouped by ACTL10-low versus ACTL10-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL10→partner) and Y-score (partner→ACTL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Cellular response to phorbol 13-acetate 12-myristate →	+0.240	+0.634	.001	.009	3	11
LUNG_SCLC	Regulation of cytokine-mediated signaling pathway →	+0.059	+1.181	<.001	<.001	3	9
BONE	Regulation of protein export from nucleus →	+0.074	+0.504	<.001	<.001	3	8
OVARY	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.115	+0.394	<.001	.008	3	8
LUNG_SCLC	Positive regulation of blood vessel branching →	+0.121	+0.778	<.001	.003	3	7
BONE	Response to hypobaric hypoxia →	+0.104	+0.399	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,764 associations by consensus.

Cellular response to phorbol 13-acetate 12-myristate by ACTL10 expression — URINARY_TRACT

Explore this box plot interactively →