ACTL10

Across TCGA cell cohorts, ACTL10 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ACTL10-associated genes across cancer lineages are CD40LG, OR10A5, and MRGPRX4. Each is linked with ACTL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTL10-to-partner and partner-to-ACTL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD40LG grouped by ACTL10-low versus ACTL10-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL10→partner) and Y-score (partner→ACTL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CD40LG →	+0.024	+4.700	<.001	.002	3	1
OVARY	OR10A5 →	+0.036	+4.029	<.001	.009	3	1
OVARY	MRGPRX4 →	+0.023	+4.700	<.001	.002	3	1
OVARY	DEFB116 →	+0.095	+4.807	<.001	.003	3	1
OVARY	OR52B4 →	+0.037	+4.807	<.001	.003	3	1
OVARY	SPATA31A7 →	+0.037	+4.990	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CD40LG by ACTL10 expression — OVARY

Explore this box plot interactively →