ACTG2

Across TCGA patient cohorts, ACTG2 mutation is significantly associated with the RNA expression of many other genes, with 270 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ACTG2-associated genes across cancer lineages are MIR1976, RN7SL479P, and RPS27P22. Each is linked with ACTG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTG2-to-partner and partner-to-ACTG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1976 grouped by ACTG2-low versus ACTG2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTG2→partner) and Y-score (partner→ACTG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR1976 →	+0.163	+4.643	<.001	.002	3	2
SKCM	RN7SL479P →	+0.052	+2.715	<.001	.005	3	2
SKCM	RPS27P22 →	+0.189	+2.241	<.001	.006	3	2
CESC	CRYGFP →	+0.069	+5.969	<.001	.002	3	2
LUAD	CTDSPL2P1 →	+0.022	+3.424	.002	.007	3	2
LUAD	SCML2P1 →	+0.062	+3.575	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 270 associations by consensus.

MIR1976 by ACTG2 expression — SKCM

Explore this box plot interactively →