ACTBL2

Across TCGA cell cohorts, ACTBL2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ACTBL2-associated genes across cancer lineages are SPATA3, FAM90A26, and PATE3. Each is linked with ACTBL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTBL2-to-partner and partner-to-ACTBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA3 grouped by ACTBL2-low versus ACTBL2-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTBL2→partner) and Y-score (partner→ACTBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SPATA3 →	+0.022	+4.169	<.001	.008	3	1
BONE	FAM90A26 →	+0.011	+4.000	<.001	.008	3	1
BONE	PATE3 →	+0.097	+4.000	.003	.008	3	1
BONE	TP53TG3E →	+0.107	+4.169	.001	.008	3	1
LUNG_NSCLC_LUAD	PSKH2 →	+0.021	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	MBD3L4 →	+0.023	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SPATA3 by ACTBL2 expression — BONE

Explore this box plot interactively →