ACTA2-AS1

Across TCGA pan-cancer cohorts, ACTA2-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ACTA2-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ACTA2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ACTA2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

KIRP, MESO, and UCS are the cancer types where ACTA2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.540	0.824	<.001	77	view →
MESO	OS	Tertile	All	0.278	0.520	.001	64	view →
UCS	DFS	Median	IV	0.885	0.440	.015	48	view →
HNSC	OS	Median	All	0.455	0.328	.010	40	view →
ACC	OS	Median	III,IV	0.535	0.935	.003	19	view →
UVM	OS	Median	III,IV	0.304	1.000	.008	18	view →
LUSC	DFS	Median	II,III,IV	0.278	0.488	.002	18	view →
BRCA	OS	Tertile	III,IV	0.645	0.303	.002	15	view →
CHOL	DFS	Median	All	0.603	0.250	.036	12	view →
SKCM	OS	Quartile	II,III,IV	0.435	0.277	.012	11	view →
LIHC	OS	Tertile	All	0.696	0.401	.002	9	view →
THYM	DFS	Median	All	0.971	0.824	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ACTA2-AS1–KIRP (OS)

Open the KIRP breakdown →