ACTA2-AS1

Across TCGA pan-cancer cohorts, ACTA2-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ACTA2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ACTA2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ACTA2-AS1 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and UCEC are the cancer types where ACTA2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACTA2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−4.022	<.001	10	view →
KICH	All	All	−0.575	<.001	7	view →
UCEC	All	All	−3.141	<.001	6	view →
BRCA	Female	All	−2.158	<.001	6	view →
KIRP	All	All	−0.457	<.001	5	view →
LUSC	All	All	−0.377	.001	5	view →
STAD	All	All	−1.038	.007	4	view →
LUAD	Male	All	+0.587	.014	3	view →
PRAD	All	All	−0.769	<.001	2	view →
ESCA	Female	All	−0.983	.044	1	view →
READ	All	All	−0.668	.039	1	view →
CHOL	All	All	+0.560	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ACTA2-AS1–BLCA

Open the BLCA breakdown →