ACSS2

Across TCGA cell cohorts, ACSS2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ACSS2-associated genes across cancer lineages are DEFA4, BPIFA1, and OR52N5. Each is linked with ACSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSS2-to-partner and partner-to-ACSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by ACSS2-low versus ACSS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSS2→partner) and Y-score (partner→ACSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.114	+3.103	.003	.004	3	1
CNS	OR52N5 →	+0.009	+4.754	<.001	.005	3	1
CNS	VWC2 →	+0.549	+4.472	<.001	.004	3	1
SKIN	MBD3L5 →	+0.029	+5.415	<.001	.004	3	1
BREAST	CD40LG →	+0.243	+4.232	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

DEFA4 by ACSS2 expression — LARGE_INTESTINE

Explore this box plot interactively →